E-democracy: exploring the current stage of e-government

Governments around the world have been pressured to implement e-Government programs in order to improve the government-citizen dialogue. The authors of this article review prior literature on such efforts to find if they lead to increased democratic participation ("e-Democracy") for the affected citizens, with a focus on the key concepts of transparency, openness, and engagement. The authors find that such efforts are a starting point toward e-Democracy, but the journey is far from complete

Can Fighting Misinformation Have a Negative Spillover Effect? How Warnings for the Threat of Misinformation Can Decrease General News Credibility

In the battle against misinformation, do negative spillover effects of communicative efforts intended to protect audiences from inaccurate information exist? Given the relatively limited prevalence of misinformation in people’s news diets, this study explores if the heightened salience of misinformation as a persistent societal threat can have an unintended spillover effect by decreasing the credibility of factually accurate news. Using an experimental design (N = 1305), we test whether credibility ratings of factually accurate news are subject to exposure to misinformation, corrective information, misinformation warnings, and news media literacy (NML) interventions relativizing the misinformation threat. Findings suggest that efforts like warning about the threat of misinformation can prime general distrust in authentic news, hinting toward a deception bias in the context of fear of misinformation being salient. Next, the successfulness of NML interventions is not straight forward if it comes to avoiding that the salience of misinformation distorts people’s creditability accuracy. We conclude that the threats of the misinformation order may not just be remedied by fighting false information, but also by reestablishing trust in legitimate news

Picture Power? The Contribution of Visuals and Text to Partisan Selective Exposure

Today’s high-choice media environment allows citizens to select news in line with their political preferences and avoid content counter to their priors. So far, however, selective exposure research has exclusively studied news selection based on textual cues, ignoring the recent proliferation of visual media. This study aimed to identify the contribution of visuals alongside text in selective exposure to pro-attitudinal, counter-attitudinal and balanced content. Using two experiments, we created a social media-style newsfeed with news items comprising matching and non-matching images and headlines about the contested issues of immigration and gun control in the U.S. By comparing selection behavior of participants with opposing prior attitudes on these topics, we pulled apart the contribution of images and headlines to selective exposure. Findings show that headlines play a far greater role in guiding selection, with the influence of images being minimal. The additional influence of partisan source cues is also considered

A single-cell survey of the small intestinal epithelium

Intestinal epithelial cells (IECs) absorb nutrients, respond to microbes, provide barrier function and help coordinate immune responses. We profiled 53,193 individual epithelial cells from mouse small intestine and organoids, and characterized novel subtypes and their gene signatures. We showed unexpected diversity of hormone-secreting enteroendocrine cells and constructed their novel taxonomy. We distinguished between two tuft cell subtypes, one of which expresses the epithelial cytokine TSLP and CD45 (Ptprc), the pan-immune marker not previously associated with non-hematopoietic cells. We also characterized how cell-intrinsic states and cell proportions respond to bacterial and helminth infections. Salmonella infection caused an increase in Paneth cells and enterocytes abundance, and broad activation of an antimicrobial program. In contrast, Heligmosomoides polygyrus caused an expansion of goblet and tuft cell populations. Our survey highlights new markers and programs, associates sensory molecules to cell types, and uncovers principles of gut homeostasis and response to pathogens

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

A single-cell survey of the small intestinal epithelium

Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures. We found unexpected diversity in hormone-secreting enteroendocrine cells and constructed the taxonomy of newly identified subtypes, and distinguished between two subtypes of tuft cell, one of which expresses the epithelial cytokine Tslp and the pan-immune marker CD45, which was not previously associated with non-haematopoietic cells. We also characterized the ways in which cell-intrinsic states and the proportions of different cell types respond to bacterial and helminth infections: Salmonella infection caused an increase in the abundance of Paneth cells and enterocytes, and broad activation of an antimicrobial program; Heligmosomoides polygyrus caused an increase in the abundance of goblet and tuft cells. Our survey highlights previously unidentified markers and programs, associates sensory molecules with cell types, and uncovers principles of gut homeostasis and response to pathogens